The SFC Prep 150 AP System is designed for efficient and automated preparative chromatography in modern drug discovery laboratories. It combines automated sample handling, column switching, and fraction collection in an open-bed design to streamline purification workflows. Using liquid CO2 with organic modifiers, it supports faster separations, reduced solvent use, and lower operating pressures. The system integrates seamlessly with MassLynx and FractionLynx for UV- or MS-triggered collection. Modular components, flexible column configurations, and precise thermal control ensure consistent performance, making it a robust and cost-effective choice for high-throughput purification demands.